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Leukocytes Are Recruited through the Bronchial Circulation to the Lung in a Spontaneously Hypertensive Rat Model of COPD

Figure 7

Adhesion molecule and chemokine expression in and around the bronchial blood vessels following 3 days, 4 weeks, or 12 weeks of tobacco smoke exposure.

Top) Representative pictures of immunohistochemical staining of E-selectin in the bronchial wall of SH rats exposed to filtered air or tobacco smoke for 3 days, 4 weeks, or 12 weeks. Arrows indicate bronchial blood vessels. Bottom) IHC staining intensity of E-selectin, VCAM, ICAM, MCP-1, and MIP-2 after 3 days, 4 weeks, or 12 weeks of tobacco smoke as scored by blinded ranking. The difference from control staining is reported as mean ± SEM, where the mean control staining at each location is set to zero. * p value<0.05 vs. filtered air. Brackets indicate comparisons between 3 days, 4 weeks and 12 weeks of smoke exposure. (staining scores were reranked prior to analysis changing the scale, see methods).

Figure 7