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Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis

Figure 9

Effect of CBD and GW9662 in rectal biopsies of patients with ulcerative colitis (UC) in the acute phase.

(A) shows the effect of CBD and GW9662 on glial activation evaluated as S100B protein expression. Western blot and relative densitometric analysis evidenced that GW9662 significantly counteracts the effect of CBD on S100B expression in biopsies of UC in acute phase. (B) shows the effect of GW9662 and CBD on iNOS protein expression and (C) nitrate production. Results are expressed as mean ± SEM of 3 experiments; °°°p<0.001 vs. untreated biopsies; **p<0.05, ***p<0.001 vs CBD.

Figure 9

doi: https://doi.org/10.1371/journal.pone.0028159.g009