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An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine

Figure 4

Functional map of Hsp90Int.

In this functionally grouped GO annotation network, nodes represent a GO term (biological process) significantly overrepresented in a group of proteins from the interactome (at least 8). The node sizes represent the term enrichment significance. Edges connect GO terms that share common sets of proteins present in Hsp90Int. Similar functional terms are grouped in colored regions and labeled with a representative name. For clarity, the original ClueGO output was edited with Adobe Illustrator. For example, some terms are highlighted in red to guide the viewer.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0026044.g004