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An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine

Figure 2

Visualization of Hsp90Int.

The full interactome containing 1'150 nodes and 8'892 edges is presented here as a zoomable PPI network with query proteins but not their interactors being colored (see inset). The sizes of the nodes reflect their level of association with partners inside the network (degree). The origins of the interactions are indicated by the color of the edge line: interologs and human interactions are represented with blue dashed and red full lines, respectively. Chaperone, core molecular chaperones such as Hsp90α and Hsp90β; TPR, tetratricopeptide repeats; CS, “CHORD and Sgt1 domain”.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0026044.g002