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Local Field Potential Modeling Predicts Dense Activation in Cerebellar Granule Cells Clusters under LTP and LTD Control

Figure 8

Simulations of the effects of long-term synaptic plasticity -II.

(A) Simulated LFP changes in vivo obtained by changing release probability (p) alone (top) or together intrinsic excitability (IE) (bottom). The rising phase of the LFP is shown on expanded time-scale. (B) The plot shows the delay changes caused by p in T-wave. The three different curves represent levels of IE (low, normal and high). Note that appropriate LTP and LTD changes like those observed experimentally occur when both p and IE change bidirectionally around the control value. Each trace is the average of 15 simulations.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0021928.g008