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Local Field Potential Modeling Predicts Dense Activation in Cerebellar Granule Cells Clusters under LTP and LTD Control

Figure 6

Mechanism of local field potential generation in vivo.

(A) Different granule cell responses generated by combining the input from 1 to 4 mossy fibers with inhibition from 0 to 4 Golgi cells (GoC). Excitation consists of a pulse train at 500 Hz and inhibition of 1 impulse occurring 4 ms after the beginning of excitation. Due to redundancy, 4 out of 20 patterns (GrC/GrC = 1/4, 2/3, 3/2, 4/1; thicker lines) are sufficient to adequately reconstruct the LFP. The T and C waves are generated independently (C has a delay of 10 ms) and then summed linearly. Schematics of the circuit are shown at the top, illustrating independent circuits for T and C. (B) The LFP in vitro is generated by different combinations of responses, four of which are shown at the top. (C) The LFP control by synaptic receptors accounts for experimental observations: T and C are increased by GABA-A receptor switch-off and reduced by subsequent NMDA receptor switch-off.

Figure 6