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HIVToolbox, an Integrated Web Application for Investigating HIV

Figure 3

Analysis of Integrase model tetramers and hetero-octamers.

Output of HIVToolbox showing surface plots of IN structural models. (A, B) IN tetramers showing domain organization (left panels) and locations of actives site residues (royal blue), proposed viral DNA binding grooves (yellow lines), proposed genomic DNA binding channel (red line), and zinc binding sites (cyan). Yellow numbers indicate the subunit too which the domain belongs. (C) IN:LEDGF hetero-octamers models showing organization of proteins (left panel) and proposed DNA binding groove (middle panel, red line). LEDGF subunits are colored grey. (D) An end-on view of the proposed host DNA binding channel in the IN:LEGDF hetero-octamer model shown in (C) (red circle).

Figure 3