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Calpain Cleavage Prediction Using Multiple Kernel Learning

Figure 6

Cleavage prediction on Calpastatin sequences.

Normalized MKL prediction scores using Position, String and SS feature sets. A: on wild type Rattus norvegicus calpastatin (gi 13540322). B: on a mutant of calpastatin, obtained by deletion of Lys176 and Glu177 (highlighted in red in sequence A and marked by a red star in sequence B). Results were cropped to residues [101–200] in the sequence. Thin blue line marks 5% top scores threshold. Thick green lines highlight “loop-out” area of calpastatin sequences (shortened in the mutant by deletion of Lys176 and Glu177) where cleavage would likely occur.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0019035.g006