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Calpain Cleavage Prediction Using Multiple Kernel Learning

Figure 4

Schematic representation of contact region between calpain and substrate sequence.

Domain II is the protease domain of calpain, while domain III binds . Amino acid sequences of domain III are less conserved than those of domain II, which are highly conserved not only between - and m-calpains but also among all calpain family members.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0019035.g004