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GPS-CCD: A Novel Computational Program for the Prediction of Calpain Cleavage Sites

Figure 3

Comparison of GPS 2.0, GPS 1.1 [24], PoPS [19], [20], SitesPrediction [21] and CaMPDB [22].

The leave-one-out performances were calculated for GPS 2.0, GPS 1.1 and PoPS. We calculated the accuracy of SitesPrediction by directly submitting the benchmark data set for the prediction. (A) The data set contains 368 cleavage sites in 130 unique substrates; (B) For CaMPDB, we took 267 cleavage sites in 104 proteins from its website [22]. The highest AROC value in CaMPDB was 0.801.

Figure 3