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Innate Immune Responses of Drosophila melanogaster Are Altered by Spaceflight

Figure 3

Humoral responses are downregulated in spaceflight larvae.

Gene Ontology (GO) categories of defense response show altered gene expression in flight larvae compared to ground-reared larvae: 30 out of the 37 classified as defense response are downregulated in flight. These include the majority of response to bacteria and in particular humoral response genes. Six experimental repeats of each of the samples (flight and ground) were used to extract RNA for microarray analysis and are represented in individual columns in the figure. Rows represent levels of individual gene expression in each of the experimental repeats. Data is shown following Z-score transformation. Red colors indicate Z-scores >0 (above mean), blue colors indicate Z-scores <0 (below mean). The gene names can be found in Tables 1 and 2.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0015361.g003