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Identification of Methylated Genes Associated with Aggressive Bladder Cancer

Figure 4

Bisulfite pyrosequencing demonstrates that extent of methylation is associated with tumor grade in non-invasive tumors.

The mean (filled circle) and 95% confidence intervals of the extent of methylation of the promoter regions of (A) FRZB, (B) KRT13, and (C) HOXB2 are depicted (y-axis) comparing low (1,2) to high (3+) grade tumors (x-axis). P-values resulting from the Wilcoxon Rank Sums demonstrate that these differences are significant for HOXB2 (P<0.01), KRT13 (P<0.01) and FRZB (P = 0.0001).

Figure 4

doi: https://doi.org/10.1371/journal.pone.0012334.g004