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Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs

Figure 3

Celastrol disorganizes mitotic spindles.

The representative immunostaining of microtubule (alpha- tubulin) and centrosome (gamma-tubulin) of the interphase and spindle morphology of mitotic HeLa cells treated for 1 hour with the indicated drugs; Celastrol (4 µM), Vinblastine (10 nM), and Taxol (10 nM).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0010318.g003