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A Live Zebrafish-Based Screening System for Human Nuclear Receptor Ligand and Cofactor Discovery

Figure 5

LT drug responses are quantifiable.

(a) Dose dependent GFP expression Shown are the dose responses for T3, KB2115 and TRIAC in TRβ tail epidermis (48 hpf) treated embryos. Treatments were done from 0.1–500 nM. GFP images show anterior-posterior tail view (imaged at 150× magnification) (b) The graph indicates average intensity of GFP signals for each treatment in percent. GFP expression was quantified using nuclei count software from MetaX files. Values for drug treated fish are shown in yellow (TRIAC), in blue (KB2115) and in red (T3).

Figure 5