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Homer1a-Dependent Crosstalk Between NMDA and Metabotropic Glutamate Receptors in Mouse Neurons

Figure 4

G-proteins interact with and inhibit NMDA channels.

A: GTPgammaS was dialyzed in cultured cerebellar granule cells through the recording pipette and NMDA currents measured before and after a depolarization pulse, as described in Fig. 3Ba and Fig. 3C. B: Control neurons (- Homer1a) or neurons expressing induced Homer1a (+ Homer1a) were exposed (+) or not (−) to DHPG, plus NMDA. Lysates were prepared from these cultures and immunoprecipitated with a pan anti-NR1 antibody, and revealed with an anti-Gbeta antibody.

Figure 4