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Inheritance of DNA Transferred from American Trypanosomes to Human Hosts

Figure 7

Model of Trypanosoma cruzi minicircle integration and replication in the human genome.

(A) Infection-induced host DNA (green) double strand-break (DSB) and integration of kDNA minicircle sequence (blue) mediated by microhomology end-joining. (B) Replication of the kDNA-LINE sequence by target-primed reverse-transcription using the autonomous recombination machinery of the LINE-1. The kDNA sequence repeat received a specific cut, and free-end pairing with a first strand transcript (green). A complementary second strand transcript is made, which can transpose to different chromosomes.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0009181.g007