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Human Ovarian Reserve from Conception to the Menopause

Figure 6

A hypothetical link between ovarian reserve and age at menopause.

This figure describes the hypothesis that individual age at menopause is determined by the peak NGF population established at around 20 weeks post-conception. The central curve is the ADC model described in Figures 1 and 4. Above and below are the hypothetical curves for an ovary having log-adjusted peak population varying from the average case by one half, one, one and a half, and two standard deviations. Under this hypothesis, a variation by, for example, one standard deviation in the initial peak population results in a one standard deviation from the average age at menopause.

Figure 6