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Investigating the Role of Mitochondrial Haplogroups in Genetic Predisposition to Meningococcal Disease

Figure 1

Analysis of population sub-structure in MD cases.

On the left, analysis of population structure in CEPH panel samples (including 225 Africans, 208 Native Americans and 278 Europeans; see text for more details), and 307 meningococcal patients, based on a 34-plex autosomal AIMs for the assignment of ancestral origin with grouping values of K = 3. Top panel (A) is the representation of membership of the samples as originally introduced in the analysis; the bottom panel (B) shows the same samples sorted by membership values. On the right, Principal Component Analysis of the same samples used in Text S1. PC1, PC2, and PC3 stand for principal components one, two and three, respectively; in rounded brackets is the amount of variation accounted by each component.

Figure 1