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Genomes2Drugs: Identifies Target Proteins and Lead Drugs from Proteome Data

Figure 4

Enrichment of P. falciparum proteome by RhuDB – DrugBank targets.

Enrichment curves were plotted as described in Figure 2. The 5283 protein malarial proteome was ranked by RhuDB. P. falciparum and malaria related hits from DrugBank were identified using keyword searching of DrugBank website [4], as shown in supplementary Table S2 online. The 〈drugbank_title〉 field entries were matched to this list of P. falciparum or malaria related drug targets. The enrichment percentage as a function of rank are shown in dark blue, while the red line shows an ideal case, and the light blue line indicates a random distribution. The insert highlights the first 500 entries.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0006195.g004