Deciphering the molecular network of Trichostatin A in regulating Alzheimer’s disease screening of core genes and mechanistic investigation based on multidimensional bioinformatics and molecular simulation
Fig 9
Cell Type Annotation and Core Gene Expression Characteristic Analysis of scRNA-seq Data.
(A). UMAP plot of annotated cell types (Astrocytes, Endothelial cells/Pericytes, Microglia, Neurons, Oligodendrocytes, OPC), clarifying the main cell populations involved in AD pathology. (B). Bar chart of cell type proportion in each sample, showing cell composition changes in AD brain. (C). Sankey diagram of the top 10 marker genes per cell type, displaying cell-specific marker genes. (D). Violin plot of core gene expression across cell clusters, revealing the cell-type-specific expression profile of core genes, and providing a cellular basis for TSA’s regulatory mechanism in AD.