JMJD3 regulates the M2-like macrophage polarization and promotes the growth of breast cancer cells via STAT6/IRF4 axis
Fig 5
Effect of JMJD3 and STAT6 regulated M2-like macrophages on the growth of MDA-MB-231 cells.
MDA-MB-231 breast cancer cells were cultured with different types of macrophage-conditioned media for 48 hours. (A, B, C) Proliferation of MDA-MB-231 breast cancer cells assessed using the CCK8 assay. (D) Apoptosis rates of MDA-MB-231 cells measured by flow cytometer. The experiments were replicated three times. * p < 0.05, ** p < 0.01, ***p < 0.001, ****p < 0.0001. Abbreviations: PMA, Phorbol 12-myristate 13-acetate; OD, optical density; PI, propidium iodide.