Prediction of protein interactions with function in protein (de-)phosphorylation
Fig 5
Critical proteins associated with SCA1 pathology.
(A) A PPI network consisting of ataxin-1, its 13 PTM-PPIs and the 3 dysregulated kinases (n = 17). Node color corresponds to fold change (blue for down- and orange for upregulated proteins, respectively) and edge width to HIPPIE interaction score [24]. (B) Enrichment analysis for rare diseases highlighted an association of the critical proteins with SCA-related terms. (C) Known drugs which may restore the levels of at least 25% of the dysregulated proteins, ranked according to their combined score (p-value, adj. p-value, z-score).