Lung gene expression and single cell analyses reveal two subsets of idiopathic pulmonary fibrosis (IPF) patients associated with different pathogenic mechanisms
Fig 5
Gene signature scores for smooth muscle/pericyte/fibroblast obtained by using CD45-/EPCAM-/CD235a- (‘Lineage-sorted cells’) data from GSE132771 (Sheppard-UCSF single cell cohort) [19] in GSE47460 (Kaminski-LGRC bulk expression cohort) [14–17] subclasses.
Cell cluster names follow labeling in S3B Fig. Labels used in S3B Fig are indicated in parentheses. A. Gene signature scores for adventitial and peribronchial fibroblast subpopulations. B. Gene signature scores for alveolar fibroblast subpopulations. C. Gene signature scores for CTHRC1+ fibroblast subpopulation. D. Gene expression scores for pericytes and smooth muscle cell populations. Adjusted p values are reported on plots.