Dominance of P-glycoprotein 12 in phenotypic resistance conversion against ivermectin in Caenorhabditis elegans
Fig 2
Evaluation of RNAi-mediated impairment of Pgp 12 expression in the WT and IVR30 strain.
(A) Percentage of L3 paralysis after 48 hours of ivermectin exposure for groups Pgp 12 silenced [RNAi+], Pgp 12 non silenced [RNAi-] and negative control [CT], cultured only in M9 medium and not exposed to ivermectin treatment. (B) Assessment L3 viability cell using propidium iodide marker after 48 hours ivermectin exposure in Pgp 12 silenced [RNAi+] and Pgp 12 non silenced [RNAi-] groups. P value refers to one-way ANOVA test with Turkey’s multiple comparisons test.