Transplantation of Oligodendrocyte Precursor Cells Improves Locomotion Deficits in Rats with Spinal Cord Irradiation Injury
Figure 5
Transplantation of Olig2+-GFP+-OPCs results in a delayed demyelination and cavitation.
(A) LFB/H&E staining showed smaller cystic cavitations in the transplanted cord than those in the sham and the control group in the dorsal funiculus. (B) Optical densities of dorsal funiculus in spinal cord was significantly increased in rats grafted with Olig2+-GFP+-OPCs, as compared to the sham and the control group (*p < 0.05, n = 12). (C) Enlargement of framed area in part a, illustrated immunostaining of MBP and NF, showing axons (green arrow) with or without myelin (red arrow). (D) Electron microscopy confirmed the structure of axons (asterisk). Bar, 200 µm (A); bar, 35 µm (C); bar, 0.5 µm (D).