Cannabinoid-Mediated Inhibition of Recurrent Excitatory Circuitry in the Dentate Gyrus in a Mouse Model of Temporal Lobe Epilepsy
Figure 3
Action potential dependence of epileptiform EPSC bursts.
A. Spontaneous burst activity recorded from a granule cell in a pilocarpine-treated mouse that survived SE. B. The bursts were completely blocked by TTX (1 µM), indicating they were action potential-dependent. Action potential-independent mEPSCs were still seen in the presence of TTX. A1 and B1 are expanded segments of A and B respectively. The recordings were made in the absence of Mg2+ and presence of bicuculline (30 µM).