Designing of a multiepitope-based vaccine against echinococcosis utilizing the potent Ag5 antigen: Immunoinformatics and simulation approaches

Rehana Parvin; Md. Habib Ullah Masum; Homaira Pervin Heema; Aklima Akter; Mohammad Alamgir Hossain; A. M. A. M. Zonaed Siddiki

doi:10.1371/journal.pone.0310510

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Open Access

Peer-reviewed

Research Article

Designing of a multiepitope-based vaccine against echinococcosis utilizing the potent Ag5 antigen: Immunoinformatics and simulation approaches

Rehana Parvin,

Roles Data curation, Formal analysis, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

Affiliation Genomics Research Group, Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram, Bangladesh
⨯
Md. Habib Ullah Masum,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Genomics and Bioinformatics, Faculty of Biotechnology and Genetic Engineering, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram, Bangladesh
⨯
Homaira Pervin Heema,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Genomics Research Group, Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram, Bangladesh
⨯
Aklima Akter,

Roles Methodology

Affiliation Genomics Research Group, Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram, Bangladesh
⨯
Mohammad Alamgir Hossain,

Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Genomics Research Group, Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram, Bangladesh
⨯
A. M. A. M. Zonaed Siddiki

Roles Conceptualization, Data curation, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: zsiddiki@gmail.com

Affiliations Genomics Research Group, Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram, Bangladesh, Nextgen Informatics Ltd, Bangladesh

https://orcid.org/0000-0003-2990-4022

⨯

Designing of a multiepitope-based vaccine against echinococcosis utilizing the potent Ag5 antigen: Immunoinformatics and simulation approaches

Rehana Parvin,
Md. Habib Ullah Masum,
Homaira Pervin Heema,
Aklima Akter,
Mohammad Alamgir Hossain,
A. M. A. M. Zonaed Siddiki

Published: February 12, 2025
https://doi.org/10.1371/journal.pone.0310510

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Vaccines
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Antigens
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Vaccine development
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B cells
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Echinococcosis
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