Induction of neutralizing antibodies against SARS-CoV-2 variants by a multivalent mRNA-lipid nanoparticle vaccine encoding SARS-CoV-2/SARS-CoV Spike protein receptor-binding domains in mice

• Qiong Zhang ,

  Contributed equally to this work with: Qiong Zhang, Shashi Tiwari

  Roles Investigation, Methodology, Validation, Writing – original draft

  Affiliation Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, United States of America

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• Shashi Tiwari ,

  Contributed equally to this work with: Qiong Zhang, Shashi Tiwari

  Roles Investigation, Methodology

  Affiliation Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, United States of America

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• Jing Wen,

  Roles Investigation, Methodology

  Affiliation Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, United States of America

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• Shaobo Wang,

  Roles Investigation, Methodology

  Affiliation Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, United States of America

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• Lingling Wang,

  Roles Methodology

  Affiliation Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, United States of America

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• Wanyu Li,

  Roles Resources

  Affiliation Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, United States of America

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• Lingzhi Zhang,

  Roles Resources

  Affiliation Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, United States of America

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• Stephen Rawling,

  Roles Resources

  Affiliation Division of Infectious Diseases, Department of Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, United States of America

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• Yong Cheng,

  Roles Resources

  Affiliation Department of NanoEngineering, University of California San Diego, La Jolla, CA, United States of America

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• Jesse Jokerst,

  Roles Resources

  Affiliation Department of NanoEngineering, University of California San Diego, La Jolla, CA, United States of America

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• Tariq M. Rana

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – review & editing

  * E-mail: trana@ucsd.edu

  Affiliation Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, Institute for Genomic Medicine, UCSD Center for AIDS Research, University of California San Diego, La Jolla, California, United States of America

  https://orcid.org/0000-0001-9558-5766

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