Cortical spheroids show strain-dependent cell viability loss and neurite disruption following sustained compression injury

• Rafael D. González-Cruz ,

  Contributed equally to this work with: Rafael D. González-Cruz, Yang Wan

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Neuroscience, Brown University, Providence, RI, United States of America, Carney Institute for Brain Science, Brown University, Providence, RI, United States of America, School of Engineering, Brown University, Providence, RI, United States of America

  https://orcid.org/0000-0001-6025-1686

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• Yang Wan ,

  Contributed equally to this work with: Rafael D. González-Cruz, Yang Wan

  Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation School of Engineering, Brown University, Providence, RI, United States of America

  ⨯
• Amina Burgess,

  Roles Investigation, Software

  Affiliation Institute for Biology, Engineering, and Medicine, Brown University Providence, RI, United States of America

  ⨯
• Dominick Calvao,

  Roles Investigation, Writing – review & editing

  Affiliation Institute for Biology, Engineering, and Medicine, Brown University Providence, RI, United States of America

  https://orcid.org/0000-0001-5886-9524

  ⨯
• William Renken,

  Roles Investigation

  Affiliation Department of Neuroscience, Brown University, Providence, RI, United States of America

  ⨯
• Francesca Vecchio,

  Roles Investigation

  Affiliation Institute for Biology, Engineering, and Medicine, Brown University Providence, RI, United States of America

  https://orcid.org/0000-0001-6314-208X

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• Christian Franck,

  Roles Funding acquisition, Writing – review & editing

  Affiliations Center for Traumatic Brain Injury, University of Wisconsin-Madison, Madison, WI, United States of America, Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States of America

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• Haneesh Kesari ,

  Roles Conceptualization, Funding acquisition, Methodology, Software, Supervision, Validation, Writing – review & editing

  * E-mail: diane_hoffman-kim@brown.edu (DHK); haneesh_kesari@brown.edu (HK)

  Affiliation School of Engineering, Brown University, Providence, RI, United States of America

  ⨯
• Diane Hoffman-Kim

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: diane_hoffman-kim@brown.edu (DHK); haneesh_kesari@brown.edu (HK)

  Affiliations Department of Neuroscience, Brown University, Providence, RI, United States of America, Carney Institute for Brain Science, Brown University, Providence, RI, United States of America, Institute for Biology, Engineering, and Medicine, Brown University Providence, RI, United States of America

  ⨯