Macrophage specific restoration of the Nrf2 gene in whole-body knockout mice ameliorates steatohepatitis induced by lipopolysaccharide from Porphyromonas gingivalis through enhanced hepatic clearance

• Kanako Chihara ,

  Contributed equally to this work with: Kanako Chihara, Kosuke Okada

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Department of Oral and Maxillofacial Surgery, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan, Doctoral Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Kosuke Okada ,

  Contributed equally to this work with: Kanako Chihara, Kosuke Okada

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Division of Medical Sciences, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan, Department of Gastroenterology, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Fumihiko Uchida,

  Roles Data curation, Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Oral and Maxillofacial Surgery, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Ikuru Miura,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Faculty of Sports and Health Science, Fukuoka University, Fukuoka-shi, Fukuoka, Japan

  https://orcid.org/0000-0002-1658-5360

  ⨯
• Shoichi Komine,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Acupuncture and Moxibustion, Faculty of Human Care, Teikyo Heisei University, Toshima-ku, Tokyo, Japan

  https://orcid.org/0000-0001-7650-9127

  ⨯
• Eiji Warabi,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Biomedical Sciences, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Takako Takayama,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Gastroenterology, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Hideo Suzuki,

  Roles Supervision, Writing – review & editing

  Affiliation Department of Gastroenterology, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Takashi Matsuzaka,

  Roles Methodology, Writing – review & editing

  Affiliation Transborder Medical Research Center, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Naomi Ishibashi-Kanno,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Oral and Maxillofacial Surgery, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Kenji Yamagata,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Oral and Maxillofacial Surgery, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Toru Yanagawa,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Oral and Maxillofacial Surgery, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Hiroki Bukawa ,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  * E-mail: shodaj@md.tsukuba.ac.jp (JS); bukawah-cuh@umin.ac.jp (HB)

  Affiliation Department of Oral and Maxillofacial Surgery, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  ⨯
• Junichi Shoda

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: shodaj@md.tsukuba.ac.jp (JS); bukawah-cuh@umin.ac.jp (HB)

  Affiliation Division of Medical Sciences, Institute of Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan

  https://orcid.org/0000-0001-9374-994X

  ⨯