Leveraging an advanced simulated moving bed approach to achieve 3-component separation for enhanced impurity removal in a non-affinity cation exchange capture step

• Serene W. Chen,

  Roles Data curation, Investigation, Validation, Writing – original draft

  Affiliation Downstream Processing Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore

  ⨯
• Zi Ying Zheng,

  Roles Formal analysis, Investigation

  Affiliation Downstream Processing Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore

  ⨯
• Farouq Bin Mahfut,

  Roles Data curation, Resources

  Affiliation Cell Line Development Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore

  ⨯
• Yuansheng Yang,

  Roles Resources

  Affiliation Cell Line Development Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore

  ⨯
• Masahiro Ogino,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Resources

  Affiliation Functional Materials Development, R&D Center, R&D and Engineering, Organo Corporation, Koto City, Japan

  ⨯
• Kazuo Okada,

  Roles Conceptualization, Formal analysis, Investigation

  Affiliation Functional Materials Development, R&D Center, R&D and Engineering, Organo Corporation, Koto City, Japan

  ⨯
• Kohei Sato,

  Roles Conceptualization, Formal analysis, Resources, Supervision

  Affiliation Functional Materials Development, R&D Center, R&D and Engineering, Organo Corporation, Koto City, Japan

  ⨯
• Wei Zhang

  Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: zhang_wei@bti.a-star.edu.sg

  Affiliation Downstream Processing Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research, Singapore, Singapore

  https://orcid.org/0000-0001-8597-5357

  ⨯