Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study

• Sandra Martín-Peláez ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: sandramartin@ugr.es

  Affiliations Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain

  https://orcid.org/0000-0002-2193-3913

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• Lluis Serra-Majem,

  Roles Conceptualization, Methodology, Project administration

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain

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• Naomi Cano-Ibáñez,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain

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• Miguel Ángel Martínez-González,

  Roles Data curation, Project administration, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Preventive Medicine and Public Health, IdiSNA, University of Navarre, Pamplona, Spain, Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0002-3917-9808

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• Jordi Salas-Salvadó,

  Roles Data curation, Funding acquisition, Project administration, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana. Reus, Spain, University Hospital of Sant Joan de Reus, Nutrition Unit, Reus, Spain, Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain

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• Dolores Corella,

  Roles Data curation, Project administration, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Preventive Medicine, University of Valencia, Valencia, Spain

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• Camille Lassale,

  Roles Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Unit of Cardiovascular Risk and Nutrition, Institut Hospital del mar de Investigaciones Médicas Municipal d’Investigació Médica (IMIM), Barcelona, Spain

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• Jose Alfredo Martínez,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain, Precision Nutrition Program, IMDEA Food, CEI UAM + CSIC, Madrid, Spain

  https://orcid.org/0000-0001-5218-6941

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• Ángel M. Alonso-Gómez,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Bioaraba Health Research Institute, Cardiovascular, Respiratory and Metabolic Area; Osakidetza Basque Health Service, Araba University Hospital; University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain

  https://orcid.org/0000-0003-2945-7509

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• Julia Wärnberg,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Nursing, School of Health Sciences. University of Malaga- Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain

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• Jesús Vioque,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain, Instituto de Investigación Sanitaria y Biomédica de Alicante, ISABIAL-UMH. Alicante, Spain

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• Dora Romaguera,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain

  ⨯
• José López-Miranda,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, Córdoba, Spain

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• Ramón Estruch,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Internal Medicine, Institut dÌnvestigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain

  https://orcid.org/0000-0003-1260-4445

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• Francisco J. Tinahones,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Virgen de la Victoria Hospital, Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA). University of Málaga, Málaga, Spain

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• José Lapetra,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain

  https://orcid.org/0000-0002-3873-5737

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• Fernando Fernández-Aranda,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain

  ⨯
• Aurora Bueno-Cavanillas,

  Roles Conceptualization, Data curation, Supervision, Writing – review & editing

  Affiliations Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain

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• Josep A. Tur,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain, Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, Palma de Mallorca, Spain

  https://orcid.org/0000-0002-6940-0761

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• Vicente Martín,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP), Institute of Health Carlos III, Madrid, Spain, Institute of Biomedicine (IBIOMED), University of León, León, Spain

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• Xavier Pintó,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain

  ⨯
• Miguel Delgado-Rodríguez,

  Roles Data curation, Writing – review & editing

  Affiliations Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain, Center for Advanced Studies in Olive Grove and Olive Oils, University of Jaén, Jaén, Spain

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• Pilar Matía,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain

  ⨯
• Josep Vidal,

  Roles Data curation, Writing – review & editing

  Affiliations CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain, Department of Endocrinology, Institut dÌnvestigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain

  ⨯
• Clotilde Vázquez,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Endocrinology and Nutrition, Hospital Fundación Jiménez-Díaz, Instituto de Investigaciones Biomédicas IISFJD. University Autónoma, Madrid, Spain

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• Lidia Daimiel,

  Roles Data curation, Writing – review & editing

  Affiliation Nutritional Genomics and Epigenomics Group, IMDEA Food, CEI UAM + CSIC, Madrid, Spain

  ⨯
• Emili Ros,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Lipid Clinic, Department of Endocrinology and Nutrition, Institut d’Investigació Biomédiques August Pi Sunyer (IDIBAPS), Hospital Clinic, Barcelona, Spain

  ⨯
• Estefanía Toledo,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Preventive Medicine and Public Health, IdiSNA, University of Navarre, Pamplona, Spain

  ⨯
• Stephanie K. Nishi,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana. Reus, Spain, University Hospital of Sant Joan de Reus, Nutrition Unit, Reus, Spain, Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain

  ⨯
• Jose V. Sorli,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Preventive Medicine, University of Valencia, Valencia, Spain

  ⨯
• Mireia Malcampo,

  Roles Data curation, Writing – review & editing

  Affiliation Unit of Cardiovascular Risk and Nutrition, Institut Hospital del mar de Investigaciones Médicas Municipal d’Investigació Médica (IMIM), Barcelona, Spain

  ⨯
• M. Ángeles Zulet,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain

  ⨯
• Anaí Moreno-Rodríguez,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Bioaraba Health Research Institute, Cardiovascular, Respiratory and Metabolic Area; Osakidetza Basque Health Service, Araba University Hospital; University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain

  ⨯
• Raquel Cueto-Galán,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Nursing, School of Health Sciences. University of Malaga- Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain

  ⨯
• Diego Vivancos-Aparicio,

  Roles Data curation, Writing – review & editing

  Affiliation Centro Salud San Vicente 1, Alicante, Spain

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• Antoni Colom,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain

  ⨯
• Antonio García-Ríos,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Reina Sofía University Hospital, University of Córdoba, Córdoba, Spain

  ⨯
• Rosa Casas,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Internal Medicine, Institut dÌnvestigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain

  ⨯
• M Rosa Bernal-López,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Virgen de la Victoria Hospital, Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA). University of Málaga, Málaga, Spain

  ⨯
• Jose Manuel Santos-Lozano,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain

  https://orcid.org/0000-0001-7097-5653

  ⨯
• Zenaida Vázquez,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Preventive Medicine and Public Health, IdiSNA, University of Navarre, Pamplona, Spain

  ⨯
• Carlos Gómez-Martínez,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana. Reus, Spain, University Hospital of Sant Joan de Reus, Nutrition Unit, Reus, Spain, Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain

  ⨯
• Carolina Ortega-Azorín,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Preventive Medicine, University of Valencia, Valencia, Spain

  https://orcid.org/0000-0001-6719-9358

  ⨯
• Jose Luís del Val,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Unit of Cardiovascular Risk and Nutrition, Institut Hospital del mar de Investigaciones Médicas Municipal d’Investigació Médica (IMIM), Barcelona, Spain

  https://orcid.org/0000-0002-0391-9368

  ⨯
• Itziar Abete,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain

  ⨯
• Amaia Goikoetxea-Bahon,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Bioaraba Health Research Institute, Cardiovascular, Respiratory and Metabolic Area; Osakidetza Basque Health Service, Araba University Hospital; University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain

  ⨯
• Elena Pascual,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Department of Preventive Medicine and Public Health, IdiSNA, University of Navarre, Pamplona, Spain

  ⨯
• Nerea Becerra-Tomás,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició Humana. Reus, Spain, University Hospital of Sant Joan de Reus, Nutrition Unit, Reus, Spain, Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain

  ⨯
• Juan J. Chillarón,

  Roles Data curation, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Unit of Cardiovascular Risk and Nutrition, Institut Hospital del mar de Investigaciones Médicas Municipal d’Investigació Médica (IMIM), Barcelona, Spain

  https://orcid.org/0000-0002-8096-1703

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•  [ ... ],
• Almudena Sánchez-Villegas

  Roles Conceptualization, Data curation, Methodology, Supervision, Writing – review & editing

  Affiliations Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain, Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain, Institute for Innovation & Sustainable Development in Food Chain. Universidad Pública de Navarra (UPNA), IdisNA, Pamplona, Spain

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