Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction

Amit Mahindra; Gonzalo Tejeda; Mario Rossi; Omar Janha; Imogen Herbert; Caroline Morris; Danielle C. Morgan; Wendy Beattie; Augusto C. Montezano; Brian Hudson; Andrew B. Tobin; David Bhella; Rhian M. Touyz; Andrew G. Jamieson; George S. Baillie; Connor M. Blair

doi:10.1371/journal.pone.0260283

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Open Access

Peer-reviewed

Research Article

Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction

Amit Mahindra,

Roles Formal analysis, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation School of Chemistry, University of Glasgow, Glasgow, United Kingdom
⨯
Gonzalo Tejeda,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Mario Rossi,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliations Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy
⨯
Omar Janha,

Roles Formal analysis, Investigation, Methodology

Affiliation Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Imogen Herbert,

Roles Formal analysis, Investigation, Methodology

Affiliation MRC Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom
⨯
Caroline Morris,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation School of Chemistry, University of Glasgow, Glasgow, United Kingdom
⨯
Danielle C. Morgan,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation School of Chemistry, University of Glasgow, Glasgow, United Kingdom
⨯
Wendy Beattie,

Roles Formal analysis, Investigation, Methodology

Affiliation Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Augusto C. Montezano,

Roles Formal analysis, Investigation, Methodology

Affiliation Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Brian Hudson,

Roles Formal analysis, Investigation, Methodology

Affiliation Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Andrew B. Tobin,

Roles Supervision, Writing – review & editing

Affiliation Institute of Molecular Cell & Systems Biology, School of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
David Bhella,

Roles Supervision, Writing – review & editing

Affiliation MRC Centre for Virus Research, University of Glasgow, Glasgow, United Kingdom

https://orcid.org/0000-0003-2096-8310

⨯
Rhian M. Touyz,

Roles Supervision, Writing – review & editing

Affiliation Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Andrew G. Jamieson,

Roles Supervision, Writing – review & editing

Affiliation School of Chemistry, University of Glasgow, Glasgow, United Kingdom
⨯
George S. Baillie,

Roles Supervision, Writing – review & editing

Affiliation Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
[ ... ],
Connor M. Blair

Roles Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: connor.blair@glasgow.ac.uk

Affiliation Institute of Cardiovascular and Medical Sciences, Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

https://orcid.org/0000-0002-9834-7402

⨯
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Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction

Amit Mahindra,
Gonzalo Tejeda,
Mario Rossi,
Omar Janha,
Imogen Herbert,
Caroline Morris,
Danielle C. Morgan,
Wendy Beattie,
Augusto C. Montezano,
Brian Hudson

Published: November 18, 2021
https://doi.org/10.1371/journal.pone.0260283

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Binding analysis
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