Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease

• Melanie Ricke-Hoch ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: hoch.melanie@mh-hannover.de

  ¶‡ SIGR and MK contributed equally to this work as first co-authors.

  Affiliation Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany

  https://orcid.org/0000-0001-5479-2275

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• Elisabeth Stelling ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ SIGR and MK contributed equally to this work as first co-authors.

  Affiliation Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany

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• Lisa Lasswitz,

  Roles Investigation, Methodology, Resources, Writing – original draft

  Affiliation Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany

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• Antonia P. Gunesch,

  Roles Investigation, Methodology, Resources, Writing – original draft

  Affiliations Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany, German Center for Infection Research, Hanover-Braunschweig Site, Braunschweig, Germany, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hanover, Germany

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• Martina Kasten,

  Roles Data curation

  Affiliation Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany

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• Francisco J. Zapatero-Belinchón,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany, Department of Clinical Microbiology, Virology & Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden

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• Graham Brogden,

  Roles Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – review & editing

  Affiliation Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany

  ⨯
• Gisa Gerold,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany, Department of Clinical Microbiology, Virology & Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden, Department of Biochemistry, University of Veterinary Medicine Hannover, Hanover Germany

  https://orcid.org/0000-0002-1326-5038

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• Thomas Pietschmann,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliations Institute of Experimental Virology, TWINCORE, Center for Experimental and Clinical Infection Research Hannover, Hanover, Germany, German Center for Infection Research, Hanover-Braunschweig Site, Braunschweig, Germany

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• Virginie Montiel,

  Roles Resources, Writing – review & editing

  Affiliation Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique, and Cliniques Universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Brussels, Belgium

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• Jean-Luc Balligand,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Pole of Pharmacology and Therapeutics, Institut de Recherche Expérimentale et Clinique, and Cliniques Universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Brussels, Belgium

  ⨯
• Federica Facciotti,

  Roles Investigation, Resources

  Affiliation Department of Experimental Oncology, European Institute of Oncology IRCCS, Milan, Italy

  ⨯
• Emilio Hirsch,

  Roles Conceptualization, Funding acquisition, Resources

  Affiliation Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino, Italy

  ⨯
• Thomas Gausepohl,

  Roles Data curation, Writing – review & editing

  Affiliation Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany

  https://orcid.org/0000-0003-1669-5911

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• Husni Elbahesh,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine in Hannover (TiHo), Hannover, Germany

  https://orcid.org/0000-0003-1243-0967

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• Guus F. Rimmelzwaan,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Research Center for Emerging Infections and Zoonoses (RIZ), University of Veterinary Medicine in Hannover (TiHo), Hannover, Germany

  ⨯
• Anne Höfer,

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hanover, Germany, Institute for Pathology, Hannover Medical School, Hanover, Germany

  ⨯
• Mark P. Kühnel,

  Roles Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hanover, Germany, Institute for Pathology, Hannover Medical School, Hanover, Germany

  ⨯
• Danny Jonigk,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), German Center for Lung Research, Hanover, Germany, Institute for Pathology, Hannover Medical School, Hanover, Germany

  ⨯
• Julian Eigendorf,

  Roles Data curation, Investigation, Project administration, Writing – review & editing

  Affiliation Institute of Sports Medicine, Hannover Medical School, Hanover, Germany

  ⨯
• Uwe Tegtbur,

  Roles Conceptualization, Investigation, Project administration, Resources, Writing – review & editing

  Affiliation Institute of Sports Medicine, Hannover Medical School, Hanover, Germany

  ⨯
• Lena Mink,

  Roles Data curation, Investigation, Resources, Writing – review & editing

  Affiliation Institute of Sports Medicine, Hannover Medical School, Hanover, Germany

  ⨯
• Michaela Scherr,

  Roles Data curation, Visualization

  Affiliation Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hanover, Germany

  ⨯
• Thomas Illig,

  Roles Funding acquisition, Methodology, Resources, Writing – review & editing

  Affiliation Hannover Unified Biobank (HUB), Hannover Medical School, Hanover, Germany

  ⨯
• Axel Schambach,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliations Institute of Experimental Hematology, Hannover Medical School, Hanover, Germany, Division of Hematology and Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, United States of America

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• Tobias J. Pfeffer,

  Roles Data curation, Investigation, Resources, Writing – review & editing

  Affiliation Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany

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• Andres Hilfiker,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany

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• Axel Haverich,

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hanover, Germany

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•  [ ... ],
• Denise Hilfiker-Kleiner

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Cardiology and Angiology, Hannover Medical School, Hanover, Germany, Department of Cardiovascular Complications of Oncologic Therapies, Medical Faculty of the Philipps University Marburg, Marburg, Germany

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