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Open Access
Peer-reviewed
Research Article
The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
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Conrad E. Z. Chan ,
Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing
* E-mail: hbrendon@dso.org.sg (BJH); trbrasel@utmb.edu (TB); p.ingram@hummingbirdbio.com (PJI); cenzuo@dso.org.sg (CEZC)
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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Shirley G. K. Seah,
Roles Data curation, Investigation, Methodology
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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De Hoe Chye,
Roles Data curation, Investigation, Methodology
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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Shane Massey,
Roles Data curation, Investigation
Affiliation Department of Microbiology & Immunology and Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX, United States of America
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Maricela Torres,
Roles Data curation, Investigation
Affiliation Department of Microbiology & Immunology and Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX, United States of America
⨯ -
Angeline P. C. Lim,
Roles Investigation, Methodology
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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Steven K. K. Wong,
Roles Investigation, Methodology
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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Jacklyn J. Y. Neo,
Roles Investigation, Methodology
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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Pui San Wong,
Roles Methodology
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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Jie Hui Lim,
Roles Methodology
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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Gary S. L. Loh,
Roles Methodology
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
⨯ -
Dongling Wang,
Roles Methodology
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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Jerome D. Boyd-Kirkup,
Roles Data curation, Investigation, Methodology, Writing – review & editing
Affiliation Hummingbird Bioscience, Singapore, Singapore
⨯ - Siyu Guan,
- Dipti Thakkar,
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Guo Hui Teo,
Roles Methodology
Affiliation Life Science Institute, National University of Singapore, Singapore, Singapore
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Kiren Purushotorman,
Roles Methodology
Affiliation Life Science Institute, National University of Singapore, Singapore, Singapore
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Paul E. Hutchinson,
Roles Methodology
Affiliation Life Science Institute, National University of Singapore, Singapore, Singapore
⨯ - Barnaby E. Young,
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Jenny G. Low,
Roles Resources
Affiliations Singapore General Hospital, Singapore, Singapore, Programme in Emerging Infectious Disease, Duke-National University of Singapore Medical School, Singapore, Singapore
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Paul A. MacAry,
Roles Resources
Affiliation Department of Microbiology & Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
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Hannes Hentze,
Roles Formal analysis, Investigation
Affiliation Experimental Drug Development Centre, Therapeutics Development, A*STAR Research Entities (ARES), Singapore, Singapore
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Venkateshan S. Prativadibhayankara,
Roles Investigation
Affiliation Experimental Drug Development Centre, Therapeutics Development, A*STAR Research Entities (ARES), Singapore, Singapore
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Kantharaj Ethirajulu,
Roles Investigation, Visualization
Affiliation Experimental Drug Development Centre, Therapeutics Development, A*STAR Research Entities (ARES), Singapore, Singapore
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Jason E. Comer,
Roles Investigation, Methodology
Affiliation Department of Microbiology & Immunology and Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX, United States of America
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Chien-Te K. Tseng,
Roles Resources, Visualization
Affiliation Department of Microbiology & Immunology and Center of Biodefense and Emerging Disease, University of Texas Medical Branch, Galveston, TX, United States of America
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Alan D. T. Barrett,
Roles Project administration, Visualization, Writing – original draft
Affiliation Department of Pathology and Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, United States of America
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Piers J. Ingram ,
Roles Conceptualization, Investigation, Supervision
* E-mail: hbrendon@dso.org.sg (BJH); trbrasel@utmb.edu (TB); p.ingram@hummingbirdbio.com (PJI); cenzuo@dso.org.sg (CEZC)
Affiliation Hummingbird Bioscience, Singapore, Singapore
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Trevor Brasel ,
Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft
* E-mail: hbrendon@dso.org.sg (BJH); trbrasel@utmb.edu (TB); p.ingram@hummingbirdbio.com (PJI); cenzuo@dso.org.sg (CEZC)
Affiliation Department of Microbiology & Immunology and Office of Regulated Nonclinical Studies, University of Texas Medical Branch, Galveston, TX, United States of America
⨯ - [ ... ],
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Brendon John Hanson
Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing
* E-mail: hbrendon@dso.org.sg (BJH); trbrasel@utmb.edu (TB); p.ingram@hummingbirdbio.com (PJI); cenzuo@dso.org.sg (CEZC)
Affiliation Biological Defence Programme, DSO National Laboratories, Singapore, Singapore
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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
- Conrad E. Z. Chan,
- Shirley G. K. Seah,
- De Hoe Chye,
- Shane Massey,
- Maricela Torres,
- Angeline P. C. Lim,
- Steven K. K. Wong,
- Jacklyn J. Y. Neo,
- Pui San Wong,
- Jie Hui Lim
- Published: June 23, 2021
- https://doi.org/10.1371/journal.pone.0253487