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Open Access
Peer-reviewed
Research Article
Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK
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Long-Sheng Chang ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Long-Sheng.Chang@nationwidechildrens.org (L-SC); dclapp@iu.edu (DWC)
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation The Research Institute at Nationwide Children’s Hospital and Department of Pediatrics, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, Ohio, United States of America
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Janet L. Oblinger ,
Contributed equally to this work with: Janet L. Oblinger, Abbi E. Smith
Roles Data curation, Formal analysis, Investigation, Writing – original draft
Affiliation The Research Institute at Nationwide Children’s Hospital and Department of Pediatrics, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, Ohio, United States of America
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Abbi E. Smith ,
Contributed equally to this work with: Janet L. Oblinger, Abbi E. Smith
Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Marc Ferrer,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America
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Steven P. Angus,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing
Affiliations Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
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Eric Hawley,
Roles Data curation, Investigation, Writing – original draft, Writing – review & editing
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Alejandra M. Petrilli,
Roles Investigation
Affiliation Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Lake Nona-Orlando, Florida, United States of America
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Roberta L. Beauchamp,
Roles Investigation
Affiliation Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Lars Björn Riecken,
Roles Investigation
Affiliation Leibniz Institute on Aging–Fritz-Lipmann Institute (FLI), Jena, Germany
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Serkan Erdin,
Roles Investigation
Affiliation Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Ming Poi,
Roles Investigation
Affiliation Division of Pharmacy Practice and Science, The Ohio State University College of Pharmacy, Columbus, Ohio, United States of America
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Jie Huang,
Roles Investigation
Affiliation The Research Institute at Nationwide Children’s Hospital and Department of Pediatrics, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, Ohio, United States of America
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Waylan K. Bessler,
Roles Data curation, Formal analysis, Investigation, Supervision
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Xiaohu Zhang,
Roles Investigation
Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America
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Rajarshi Guha,
Roles Investigation
Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America
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Craig Thomas,
Roles Investigation
Affiliation Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, United States of America
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Sarah S. Burns,
Roles Investigation
Affiliation The Research Institute at Nationwide Children’s Hospital and Department of Pediatrics, Center for Childhood Cancer and Blood Diseases, The Ohio State University College of Medicine, Columbus, Ohio, United States of America
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Thomas S. K. Gilbert,
Roles Data curation, Investigation
Affiliation University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
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Li Jiang,
Roles Investigation
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Xiaohong Li,
Roles Investigation
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Qingbo Lu,
Roles Investigation
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Jin Yuan,
Roles Investigation
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Yongzheng He,
Roles Investigation
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Shelley A. H. Dixon,
Roles Data curation, Investigation, Methodology
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Andrea Masters,
Roles Data curation, Formal analysis, Investigation, Writing – original draft
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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David R. Jones,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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Charles W. Yates,
Roles Conceptualization, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
Affiliation Department of Otolaryngology and Head/Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
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Stephen J. Haggarty ,
Roles Investigation
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Salvatore La Rosa ,
Roles Funding acquisition, Writing – original draft, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Children’s Tumor Foundation, New York, New York, United States of America
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D. Bradley Welling ,
Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital and Harvard University, Boston, Massachusetts, United States of America
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Anat O. Stemmer-Rachamimov ,
Roles Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Scott R. Plotkin ,
Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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James F. Gusella ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Center for Genomic Medicine, Massachusetts General Hospital and Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts, United States of America
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Justin Guinney,
Roles Data curation, Funding acquisition
Affiliation Sage Bionetworks, Seattle, Washington, United States of America
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Helen Morrison ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Leibniz Institute on Aging–Fritz-Lipmann Institute (FLI), Jena, Germany
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Vijaya Ramesh ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Massachusetts General Hospital and Department of Neurology, Center for Genomic Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
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Cristina Fernandez-Valle ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Lake Nona-Orlando, Florida, United States of America
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Gary L. Johnson ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
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Jaishri O. Blakeley ,
Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Departments of Neurology, Neurosurgery and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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D. Wade Clapp ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Long-Sheng.Chang@nationwidechildrens.org (L-SC); dclapp@iu.edu (DWC)
¶Members of the Synodos for NF2 Consortium. Please see the Acknowledgements for full member list.
Affiliation Department of Pediatrics, Indiana University, School of Medicine, Indianapolis, Indiana, United States of America
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- on behalf of the Synodos for NF2 Consortium
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Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK
- Long-Sheng Chang,
- Janet L. Oblinger,
- Abbi E. Smith,
- Marc Ferrer,
- Steven P. Angus,
- Eric Hawley,
- Alejandra M. Petrilli,
- Roberta L. Beauchamp,
- Lars Björn Riecken,
- Serkan Erdin
- Published: July 15, 2021
- https://doi.org/10.1371/journal.pone.0252048