Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts

• Nobutoshi Nawa ,

  Contributed equally to this work with: Nobutoshi Nawa, Katsuya Hirata, Keiji Kawatani

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

  ⨯
• Katsuya Hirata ,

  Contributed equally to this work with: Nobutoshi Nawa, Katsuya Hirata, Keiji Kawatani

  Roles Investigation, Writing – review & editing

  Affiliations Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Neonatal Medicine, Osaka Women’s and Children’s Hospital, Izumi, Osaka, Japan

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• Keiji Kawatani ,

  Contributed equally to this work with: Nobutoshi Nawa, Katsuya Hirata, Keiji Kawatani

  Roles Investigation, Writing – review & editing

  Affiliation Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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• Toshihiko Nambara,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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• Sayaka Omori,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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• Kimihiko Banno,

  Roles Investigation, Writing – review & editing

  Affiliations Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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• Chikara Kokubu,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Department of Genome Biology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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• Junji Takeda,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Department of Genome Biology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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• Ken Nishimura,

  Roles Methodology, Writing – review & editing

  Affiliation Laboratory of Gene Regulation, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Manami Ohtaka,

  Roles Methodology, Writing – review & editing

  Affiliation Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

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• Mahito Nakanishi,

  Roles Methodology, Writing – review & editing

  Affiliation Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

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• Daisuke Okuzaki,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

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• Hidetoshi Taniguchi,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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• Hitomi Arahori,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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• Kazuko Wada,

  Roles Resources, Writing – review & editing

  Affiliations Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan, Department of Neonatal Medicine, Osaka Women’s and Children’s Hospital, Izumi, Osaka, Japan

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• Yasuji Kitabatake ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: ykitaba@ped.med.osaka-u.ac.jp

  Affiliation Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

  http://orcid.org/0000-0002-2907-9512

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•  [ ... ],
• Keiichi Ozono

  Roles Supervision, Writing – review & editing

  Affiliation Department of Pediatrics, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

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