Lenvatinib plus anti-PD-1 antibody combination treatment activates CD8⁺ T cells through reduction of tumor-associated macrophage and activation of the interferon pathway

• Yu Kato,

  Roles Conceptualization, Investigation, Project administration, Writing – original draft

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

  http://orcid.org/0000-0003-1662-6983

  ⨯
• Kimiyo Tabata,

  Roles Investigation

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

  ⨯
• Takayuki Kimura,

  Roles Investigation, Project administration

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

  ⨯
• Ayako Yachie-Kinoshita,

  Roles Investigation, Methodology

  Affiliation The Systems Biology Institute, Shinagawa, Tokyo, Japan

  ⨯
• Yoichi Ozawa,

  Roles Investigation

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

  ⨯
• Kazuhiko Yamada,

  Roles Investigation

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

  ⨯
• Junichi Ito,

  Roles Investigation, Methodology

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

  ⨯
• Sho Tachino,

  Roles Investigation

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

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• Yusaku Hori,

  Roles Investigation

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

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• Masahiro Matsuki,

  Roles Investigation

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

  ⨯
• Yukiko Matsuoka,

  Roles Supervision

  Affiliation The Systems Biology Institute, Shinagawa, Tokyo, Japan

  ⨯
• Samik Ghosh,

  Roles Supervision

  Affiliation The Systems Biology Institute, Shinagawa, Tokyo, Japan

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• Hiroaki Kitano,

  Roles Supervision

  Affiliation The Systems Biology Institute, Shinagawa, Tokyo, Japan

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• Kenichi Nomoto,

  Roles Supervision, Writing – review & editing

  Affiliation Oncology Business Group, Eisai Inc., Woodcliff Lake, New Jersey, United States of America

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• Junji Matsui ,

  Roles Supervision, Writing – review & editing

  * E-mail: y-funahashi@hhc.eisai.co.jp (YF); Junji_Matsui@eisai.com (JM)

  Affiliations Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan, Oncology Business Group, Eisai Inc., Woodcliff Lake, New Jersey, United States of America

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•  [ ... ],
• Yasuhiro Funahashi

  Roles Conceptualization, Supervision, Writing – review & editing

  * E-mail: y-funahashi@hhc.eisai.co.jp (YF); Junji_Matsui@eisai.com (JM)

  Affiliation Tsukuba Research Laboratories, Eisai Co., Ltd., Tsukuba, Ibaraki, Japan

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