General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels

Jun-ichi Kishikawa; Yuki Inoue; Makoto Fujikawa; Kenji Nishimura; Atsuko Nakanishi; Tsutomu Tanabe; Hiromi Imamura; Ken Yokoyama

doi:10.1371/journal.pone.0190213

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Open Access

Peer-reviewed

Research Article

General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels

Jun-ichi Kishikawa,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto, Japan
⨯
Yuki Inoue,

Roles Data curation, Formal analysis, Writing – original draft

Current address: Graduate School of Biological Sciences, Nara Institute of Science Technology, Ikoma-city, Nara, Japan

Affiliation Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto, Japan
⨯
Makoto Fujikawa,

Roles Conceptualization, Data curation, Formal analysis, Writing – original draft

Affiliation Departmet of Pharmacology Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
⨯
Kenji Nishimura,

Roles Conceptualization, Data curation, Formal analysis

Affiliation Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto, Japan
⨯
Atsuko Nakanishi,

Roles Data curation, Formal analysis

Affiliation Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto, Japan
⨯
Tsutomu Tanabe,

Roles Conceptualization, Supervision

Affiliation Departmet of Pharmacology Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
⨯
Hiromi Imamura ,

Roles Conceptualization, Data curation, Formal analysis, Project administration, Writing – original draft

* E-mail: imamura@lif.kyoto-u.ac.jp (HI); yokoken@cc.kyoto-su.ac.jp (KY)

Affiliation Graduate School of Biostudies, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto, Japan
⨯
Ken Yokoyama

Roles Conceptualization, Investigation, Project administration, Writing – original draft

* E-mail: imamura@lif.kyoto-u.ac.jp (HI); yokoken@cc.kyoto-su.ac.jp (KY)

Affiliation Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kita-ku, Kyoto, Japan

http://orcid.org/0000-0002-6813-1096

⨯

General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels

Jun-ichi Kishikawa,
Yuki Inoue,
Makoto Fujikawa,
Kenji Nishimura,
Atsuko Nakanishi,
Tsutomu Tanabe,
Hiromi Imamura,
Ken Yokoyama

Published: January 3, 2018
https://doi.org/10.1371/journal.pone.0190213

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Anesthetics
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Mitochondria
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Membrane potential
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In vivo imaging
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Chemical synthesis
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Mitochondrial membrane
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