Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation

• Thomas W. Winkler,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

  http://orcid.org/0000-0003-0292-5421

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• Anne E. Justice,

  Roles Data curation, Visualization, Writing – review & editing

  Affiliation Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States of America

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• L. Adrienne Cupples,

  Roles Visualization, Writing – review & editing

  Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America, NHLBI Framingham Heart Study, Framingham, MA, United States of America

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• Florian Kronenberg,

  Roles Supervision, Visualization, Writing – review & editing

  Affiliation Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria

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• Zoltán Kutalik ,

  Contributed equally to this work with: Zoltán Kutalik, Iris M. Heid

  Roles Data curation, Formal analysis, Funding acquisition, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Social and Preventive Medicine, CHUV-UNIL, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Lausanne, Switzerland

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• Iris M. Heid ,

  Contributed equally to this work with: Zoltán Kutalik, Iris M. Heid

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: iris.heid@klinik.uni-regensburg.de

  Affiliation Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

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• the GIANT consortium

  ¶Membership of the GIANT consortium is provided in S3 Note.

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