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Open Access
Peer-reviewed
Research Article
The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys
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Sheo B. Singh ,
Contributed equally to this work with: Sheo B. Singh, Ling Kang
* E-mail: sbsingh101@gmail.com (SBS); Hong-Ping_Guan@merck.com (HPG)
Affiliation Departments of Discovery Chemistry, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Ling Kang ,
Contributed equally to this work with: Sheo B. Singh, Ling Kang
Affiliation Department of Cardiometabolic Disease, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Andrea R. Nawrocki,
Affiliation Department of Pharmacology, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Dan Zhou,
Affiliation Department of Pharmacology, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Margaret Wu,
Affiliation Department of Cardiometabolic Disease, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Stephen Previs,
Affiliation Department of Cardiometabolic Disease, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Corey Miller,
Affiliation Department of Imaging and Biomarker, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Haiying Liu,
Affiliation Department of Imaging and Biomarker, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Catherine D. G. Hines,
Affiliation Department of Translational Imaging Biomarkers, Merck Research Laboratories, 770 Sumneytown Pike, West Point, PA, 19486, United States of America
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Maria Madeira,
Affiliation Department of PKPD, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Jin Cao,
Affiliation Department of Imaging and Biomarker, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Kithsiri Herath,
Affiliation Department of Cardiometabolic Disease, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Liangsu Wang,
Affiliation Department of Cardiometabolic Disease, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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David E. Kelley,
Affiliation Department of Cardiometabolic Disease, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Cai Li,
Affiliation Department of Pharmacology, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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Hong-Ping Guan
* E-mail: sbsingh101@gmail.com (SBS); Hong-Ping_Guan@merck.com (HPG)
Affiliation Department of Cardiometabolic Disease, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ, 07033, United States of America
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The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys
- Sheo B. Singh,
- Ling Kang,
- Andrea R. Nawrocki,
- Dan Zhou,
- Margaret Wu,
- Stephen Previs,
- Corey Miller,
- Haiying Liu,
- Catherine D. G. Hines,
- Maria Madeira
- Published: October 3, 2016
- https://doi.org/10.1371/journal.pone.0164133