A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

• Natalia J. Martinez ,

  Contributed equally to this work with: Natalia J. Martinez, Ganesha Rai

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• Ganesha Rai ,

  Contributed equally to this work with: Natalia J. Martinez, Ganesha Rai

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• Adam Yasgar,

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• Wendy A. Lea,

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• Hongmao Sun,

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• Yuhong Wang,

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• Diane K. Luci,

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• Shyh-Ming Yang,

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• Kana Nishihara,

  Affiliations National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America, Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo, Kyoto 606–8501, Japan

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• Shunichi Takeda,

  Affiliation Department of Neurosurgery, John Hopkins University, Baltimore, MD 21231, United States of America

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• Mohiuddin Sagor,

  Affiliation Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo, Kyoto 606–8501, Japan

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• Irina Earnshaw,

  Affiliation Department of Radiation Genetics, Graduate School of Medicine, Kyoto University, Yoshidakonoe, Sakyo, Kyoto 606–8501, Japan

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• Tetsuya Okada,

  Affiliation Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwake, Sakyo, Kyoto 606–8502, Japan

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• Kazutoshi Mori,

  Affiliation Department of Biophysics, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwake, Sakyo, Kyoto 606–8502, Japan

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• Kelli Wilson,

  Affiliations National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America, Department of Neurosurgery, John Hopkins University, Baltimore, MD 21231, United States of America

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• Gregory J. Riggins,

  Affiliation Department of Neurosurgery, John Hopkins University, Baltimore, MD 21231, United States of America

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• Menghang Xia,

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• Maurizio Grimaldi,

  Affiliation Laboratory of Neuropharmacology, Department of Biochemistry and Molecular Biology, Southern Research Institute, Birmingham, AL 35205, United States of America

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• Ajit Jadhav,

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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• David J. Maloney ,

  * E-mail: asimeono@mail.nih.gov (AS); maloneyd@mail.nih.gov (DJM)

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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•  [ ... ],
• Anton Simeonov

  * E-mail: asimeono@mail.nih.gov (AS); maloneyd@mail.nih.gov (DJM)

  Affiliation National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, 20850, United States of America

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