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Open Access
Peer-reviewed
Research Article
Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer’s Disease
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Celeste Sassi,
Affiliations Reta Lila, Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America, Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charite’ Universitätmedizin, Berlin, Germany, German Center for Neurodegenerative Diseases (DZNE), Berlin site, Germany
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Perry G. Ridge,
Affiliation Departments of Biology, Neuroscience, Brigham Young University, Provo, UT, United States of America
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Michael A. Nalls,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America
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Raphael Gibbs,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America
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Jinhui Ding,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America
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Michelle K. Lupton,
Affiliations King's College London Institute of Psychiatry, London, United Kingdom, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
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Claire Troakes,
Affiliation King's College London Institute of Psychiatry, London, United Kingdom
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Katie Lunnon,
Affiliation King's College London Institute of Psychiatry, London, United Kingdom
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Safa Al-Sarraj,
Affiliation King's College London Institute of Psychiatry, London, United Kingdom
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Kristelle S. Brown,
Affiliation Translation Cell Sciences-Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom
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Christopher Medway,
Affiliation Translation Cell Sciences-Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom
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Jenny Lord,
Affiliation Translation Cell Sciences-Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom
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James Turton,
Affiliation Translation Cell Sciences-Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom
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ARUK Consortium ,
¶Membership of The Alzheimer’s Research UK (ARUK) Consortium is provided in the Acknowledgments
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Kevin Morgan,
Affiliation Translation Cell Sciences-Human Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom
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John F. Powell,
Affiliation King's College London Institute of Psychiatry, London, United Kingdom
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John S. Kauwe,
Affiliation Departments of Biology, Neuroscience, Brigham Young University, Provo, UT, United States of America
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Carlos Cruchaga,
Affiliation Washington University, Division of Biology and Biomedical Sciences St. Louis, MO, United States of America
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Jose Bras,
Affiliation Reta Lila, Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Alison M. Goate,
Affiliation Icahn School of Medicine at Mount Sinai, Icahn Medical Institute, New York, NY, United States of America
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Andrew B. Singleton,
Affiliation Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America
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Rita Guerreiro,
Affiliation Reta Lila, Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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John Hardy
* E-mail: j.hardy@ucl.ac.uk
Affiliation Reta Lila, Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom
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Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer’s Disease
- Celeste Sassi,
- Perry G. Ridge,
- Michael A. Nalls,
- Raphael Gibbs,
- Jinhui Ding,
- Michelle K. Lupton,
- Claire Troakes,
- Katie Lunnon,
- Safa Al-Sarraj,
- Kristelle S. Brown
- Published: June 1, 2016
- https://doi.org/10.1371/journal.pone.0150079