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Open Access
Peer-reviewed
Research Article
In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors
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David Gothard ,
* E-mail: D.Gothard@soton.ac.uk (DG); roco@soton.ac.uk (ROCO)
Affiliation Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom
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Emma L. Smith,
Affiliation Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom
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Janos M. Kanczler,
Affiliation Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom
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Cameron R. Black,
Affiliation Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom
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Julia A. Wells,
Affiliation Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom
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Carol A. Roberts,
Affiliation Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom
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Lisa J. White,
Affiliation Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Pharmacy, University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD, United Kingdom
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Omar Qutachi,
Affiliation Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Pharmacy, University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD, United Kingdom
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Heather Peto,
Affiliation Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Pharmacy, University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD, United Kingdom
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Hassan Rashidi,
Affiliation Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Pharmacy, University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD, United Kingdom
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Luis Rojo,
Affiliations Department of Materials, Imperial College London, Royal School of Mines, London, SW7 2AZ, United Kingdom, Department of Bioengineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom, Institute for Biomedical Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom, Biomaterials, Biomimetics, Biophotonics Research Division, King's College London, Dental Institute, Guy's Hospital, Tower Wing, London Bridge, London SE1 9RT, United Kingdom
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Molly M. Stevens,
Affiliations Department of Materials, Imperial College London, Royal School of Mines, London, SW7 2AZ, United Kingdom, Department of Bioengineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom, Institute for Biomedical Engineering, Imperial College London, South Kensington Campus, London, SW7 2AZ, United Kingdom
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Alicia J. El Haj,
Affiliation Institute for Science and Technology in Medicine, Keele University, Guy Hilton Research Centre, Stoke-on-Trent, ST4 7BQ, United Kingdom
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Felicity R. A. J. Rose,
Affiliation Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Pharmacy, University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD, United Kingdom
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Kevin M. Shakesheff,
Affiliations Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, School of Pharmacy, University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD, United Kingdom, Locate Therapeutics Limited, MediCity, Nottingham, NG90 6BH, United Kingdom
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Richard O. C. Oreffo
* E-mail: D.Gothard@soton.ac.uk (DG); roco@soton.ac.uk (ROCO)
Affiliation Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, United Kingdom
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In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors
- David Gothard,
- Emma L. Smith,
- Janos M. Kanczler,
- Cameron R. Black,
- Julia A. Wells,
- Carol A. Roberts,
- Lisa J. White,
- Omar Qutachi,
- Heather Peto,
- Hassan Rashidi
- Published: December 16, 2015
- https://doi.org/10.1371/journal.pone.0145080