Development and Validation of a Next-Generation Sequencing Assay for BRCA1 and BRCA2 Variants for the Clinical Laboratory

Charles M. Strom; Steven Rivera; Christopher Elzinga; Taraneh Angeloni; Sun Hee Rosenthal; Dana Goos-Root; Martin Siaw; Jamie Platt; Cory Braastadt; Linda Cheng; David Ross; Weimin Sun

doi:10.1371/journal.pone.0136419

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Open Access

Peer-reviewed

Research Article

Development and Validation of a Next-Generation Sequencing Assay for BRCA1 and BRCA2 Variants for the Clinical Laboratory

Charles M. Strom ,

* E-mail: charles.m.strom@questdiagnostics.com

Affiliation Department of Genetics, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States of America
⨯
Steven Rivera,

Affiliation Department of Genetics, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States of America
⨯
Christopher Elzinga,

Affiliation Athena / Quest Diagnostics, Marlborough, MA, United States of America
⨯
Taraneh Angeloni,

Affiliation Department of Genetics, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States of America
⨯
Sun Hee Rosenthal,

Affiliation Department of Genetics, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States of America
⨯
Dana Goos-Root,

Affiliation Department of Genetics, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States of America
⨯
Martin Siaw,

Affiliation Department of Genetics, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States of America
⨯
Jamie Platt,

Affiliation Department of Genetics, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States of America
⨯
Cory Braastadt,

Affiliation Athena / Quest Diagnostics, Marlborough, MA, United States of America
⨯
Linda Cheng,

Affiliation Department of Genetics, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States of America
⨯
David Ross,

Affiliation Celera / Quest Diagnostics, Alameda, CA, United States of America
⨯
Weimin Sun

Affiliation Department of Genetics, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, United States of America
⨯

Development and Validation of a Next-Generation Sequencing Assay for BRCA1 and BRCA2 Variants for the Clinical Laboratory

Charles M. Strom,
Steven Rivera,
Christopher Elzinga,
Taraneh Angeloni,
Sun Hee Rosenthal,
Dana Goos-Root,
Martin Siaw,
Jamie Platt,
Cory Braastadt,
Linda Cheng

Published: August 21, 2015
https://doi.org/10.1371/journal.pone.0136419

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