Particulate Matter from Both Heavy Fuel Oil and Diesel Fuel Shipping Emissions Show Strong Biological Effects on Human Lung Cells at Realistic and Comparable In Vitro Exposure Conditions

• Sebastian Oeder ,

  Contributed equally to this work with: Sebastian Oeder, Tamara Kanashova, Olli Sippula, Sean C. Sapcariu, Thorsten Streibel, Jose Manuel Arteaga-Salas, Johannes Passig

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Center of Allergy and Environment (ZAUM), Helmholtz Zentrum München and Technische Universität München, Member of the German Center for Lung Research (DZL), Munich, Germany, CK-CARE, Christine Kühne Center for Allergy Research and Education, Davos, Switzerland

  ⨯
• Tamara Kanashova ,

  Contributed equally to this work with: Sebastian Oeder, Tamara Kanashova, Olli Sippula, Sean C. Sapcariu, Thorsten Streibel, Jose Manuel Arteaga-Salas, Johannes Passig

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Mass Spectrometry Core Unit, Max Delbrück Center for Molecular Medicine Berlin-Buch, Germany

  ⨯
• Olli Sippula ,

  Contributed equally to this work with: Sebastian Oeder, Tamara Kanashova, Olli Sippula, Sean C. Sapcariu, Thorsten Streibel, Jose Manuel Arteaga-Salas, Johannes Passig

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, University of Eastern Finland, Department of Environmental Science, P.O. Box 1627, FI-70211 Kuopio, Finland

  ⨯
• Sean C. Sapcariu ,

  Contributed equally to this work with: Sebastian Oeder, Tamara Kanashova, Olli Sippula, Sean C. Sapcariu, Thorsten Streibel, Jose Manuel Arteaga-Salas, Johannes Passig

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362 Esch-Belval, Luxembourg

  ⨯
• Thorsten Streibel ,

  Contributed equally to this work with: Sebastian Oeder, Tamara Kanashova, Olli Sippula, Sean C. Sapcariu, Thorsten Streibel, Jose Manuel Arteaga-Salas, Johannes Passig

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Joint Mass Spectrometry Centre, Chair of Analytical Chemistry, Institute of Chemistry, University Rostock, Rostock, Germany, Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Jose Manuel Arteaga-Salas ,

  Contributed equally to this work with: Sebastian Oeder, Tamara Kanashova, Olli Sippula, Sean C. Sapcariu, Thorsten Streibel, Jose Manuel Arteaga-Salas, Johannes Passig

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Johannes Passig ,

  Contributed equally to this work with: Sebastian Oeder, Tamara Kanashova, Olli Sippula, Sean C. Sapcariu, Thorsten Streibel, Jose Manuel Arteaga-Salas, Johannes Passig

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Joint Mass Spectrometry Centre, Chair of Analytical Chemistry, Institute of Chemistry, University Rostock, Rostock, Germany

  ⨯
• Marco Dilger,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Institute for Technical Chemistry (ITC), Karlsruhe Institute of Technology, Campus North, Karlsruhe, Germany, Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology, Campus North, Karlsruhe, Germany

  ⨯
• Hanns-Rudolf Paur,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Institute for Technical Chemistry (ITC), Karlsruhe Institute of Technology, Campus North, Karlsruhe, Germany

  ⨯
• Christoph Schlager,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Institute for Technical Chemistry (ITC), Karlsruhe Institute of Technology, Campus North, Karlsruhe, Germany

  ⨯
• Sonja Mülhopt,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Institute for Technical Chemistry (ITC), Karlsruhe Institute of Technology, Campus North, Karlsruhe, Germany

  ⨯
• Silvia Diabaté,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology, Campus North, Karlsruhe, Germany

  ⨯
• Carsten Weiss,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Institute of Toxicology and Genetics (ITG), Karlsruhe Institute of Technology, Campus North, Karlsruhe, Germany

  ⨯
• Benjamin Stengel,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Chair of Piston Machines and Internal Combustion Engines, University Rostock, Rostock, Germany

  ⨯
• Rom Rabe,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Chair of Piston Machines and Internal Combustion Engines, University Rostock, Rostock, Germany

  ⨯
• Horst Harndorf,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Chair of Piston Machines and Internal Combustion Engines, University Rostock, Rostock, Germany

  ⨯
• Tiina Torvela,

  Affiliation University of Eastern Finland, Department of Environmental Science, P.O. Box 1627, FI-70211 Kuopio, Finland

  ⨯
• Jorma K. Jokiniemi,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, University of Eastern Finland, Department of Environmental Science, P.O. Box 1627, FI-70211 Kuopio, Finland, VTT Technical Research Centre of Finland, P.O. Box 1000, FI-02044 VTT, Espoo, Finland

  ⨯
• Maija-Riitta Hirvonen,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, University of Eastern Finland, Department of Environmental Science, P.O. Box 1627, FI-70211 Kuopio, Finland, National Institute for Health and Welfare, Department of Environmental Health, P.O. Box 95, FI-70701, Kuopio, Finland

  ⨯
• Carsten Schmidt-Weber,

  Affiliation Center of Allergy and Environment (ZAUM), Helmholtz Zentrum München and Technische Universität München, Member of the German Center for Lung Research (DZL), Munich, Germany

  ⨯
• Claudia Traidl-Hoffmann,

  Affiliations CK-CARE, Christine Kühne Center for Allergy Research and Education, Davos, Switzerland, Institute of environmental medicine, UNIKA-T, Technische Universität, Munich, Germany

  ⨯
• Kelly A. BéruBé,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Lung and Particle Research Group, School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom

  ⨯
• Anna J. Wlodarczyk,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Lung and Particle Research Group, School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom

  ⨯
• Zoë Prytherch,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Lung and Particle Research Group, School of Biosciences, Cardiff University, Cardiff, Wales, United Kingdom

  ⨯
• Bernhard Michalke,

  Affiliation Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München—German Research Center for Environmental Health GmbH, Neuherberg, Germany

  ⨯
• Tobias Krebs,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Vitrocell GmbH, Waldkirch, Germany

  ⨯
• André S. H. Prévôt,

  Affiliation Laboratory of Atmospheric Chemistry, Paul Scherrer Institute (PSI), Villigen, Switzerland

  ⨯
• Michael Kelbg,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Institute of Physics, University Rostock, Rostock, Germany

  ⨯
• Josef Tiggesbäumker,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Institute of Physics, University Rostock, Rostock, Germany

  ⨯
• Erwin Karg,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Gert Jakobi,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Sorana Scholtes,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Jürgen Schnelle-Kreis,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Jutta Lintelmann,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Georg Matuschek,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Martin Sklorz,

  Affiliation Joint Mass Spectrometry Centre, Chair of Analytical Chemistry, Institute of Chemistry, University Rostock, Rostock, Germany

  ⨯
• Sophie Klingbeil,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Joint Mass Spectrometry Centre, Chair of Analytical Chemistry, Institute of Chemistry, University Rostock, Rostock, Germany

  ⨯
• Jürgen Orasche,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Patrick Richthammer,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Laarnie Müller,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Michael Elsasser,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Ahmed Reda,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Thomas Gröger,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Benedikt Weggler,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Theo Schwemer,

  Affiliation Joint Mass Spectrometry Centre, Chair of Analytical Chemistry, Institute of Chemistry, University Rostock, Rostock, Germany

  ⨯
• Hendryk Czech,

  Affiliation Joint Mass Spectrometry Centre, Chair of Analytical Chemistry, Institute of Chemistry, University Rostock, Rostock, Germany

  ⨯
• Christopher P. Rüger,

  Affiliation Joint Mass Spectrometry Centre, Chair of Analytical Chemistry, Institute of Chemistry, University Rostock, Rostock, Germany

  ⨯
• Gülcin Abbaszade,

  Affiliation Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Christian Radischat,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Joint Mass Spectrometry Centre, Chair of Analytical Chemistry, Institute of Chemistry, University Rostock, Rostock, Germany

  ⨯
• Karsten Hiller,

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-4362 Esch-Belval, Luxembourg

  ⨯
• Jeroen T. M. Buters ,

  ¶‡ These authors also contributed equally to the manuscript.

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Center of Allergy and Environment (ZAUM), Helmholtz Zentrum München and Technische Universität München, Member of the German Center for Lung Research (DZL), Munich, Germany, CK-CARE, Christine Kühne Center for Allergy Research and Education, Davos, Switzerland

  ⨯
• Gunnar Dittmar ,

  ¶‡ These authors also contributed equally to the manuscript.

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Mass Spectrometry Core Unit, Max Delbrück Center for Molecular Medicine Berlin-Buch, Germany

  ⨯
•  [ ... ],
• Ralf Zimmermann

  * E-mail: ralf.zimmermann@helmholtz-muenchen.de

  ¶‡ These authors also contributed equally to the manuscript.

  Affiliations HICE—Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health—Aerosols and Health, www.hice-vi.eu, Neuherberg, Rostock, Munich, Karlsruhe, Berlin, Waldkirch, Germany, Kuopio, Finland, Cardiff, UK, Esch-Belval, Luxembourg, Joint Mass Spectrometry Centre, Chair of Analytical Chemistry, Institute of Chemistry, University Rostock, Rostock, Germany, Joint Mass Spectrometry Centre, CMA—Comprehensive Molecular Analytics, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• [ view all ]
• [ view less ]