CRISPR-Cas9-Based Knockout of the Prion Protein and Its Effect on the Proteome

Open Access

Peer-reviewed

Research Article

Mohadeseh Mehrabian,

Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
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Dylan Brethour,

Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
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Sarah MacIsaac,

Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
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Jin Kyu Kim,

Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
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C . Geeth Gunawardana,

Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
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Hansen Wang,

Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
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Gerold Schmitt-Ulms

* E-mail: g.schmittulms@utoronto.ca

Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
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Cloning
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Proteomes
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Mammalian genomics
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Cytoskeletal proteins
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CRISPR
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Genetically modified animals
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Guide RNA
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Polymerase chain reaction
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