No Evidence of Harms of Probiotic Lactobacillus rhamnosus GG ATCC 53103 in Healthy Elderly—A Phase I Open Label Study to Assess Safety, Tolerability and Cytokine Responses

Patricia L. Hibberd; Lauren Kleimola; Anne-Maria Fiorino; Christine Botelho; Miriam Haverkamp; Irina Andreyeva; Debra Poutsiaka; Claire Fraser; Gloria Solano-Aguilar; David R. Snydman

doi:10.1371/journal.pone.0113456

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Peer-reviewed

Research Article

No Evidence of Harms of Probiotic Lactobacillus rhamnosus GG ATCC 53103 in Healthy Elderly—A Phase I Open Label Study to Assess Safety, Tolerability and Cytokine Responses

Patricia L. Hibberd ,

* E-mail: phibberd@partners.org

Affiliation Division of Global Health, Massachusetts General Hospital for Children, Boston, MA, United States of America
⨯
Lauren Kleimola,

Affiliation Division of Global Health, Massachusetts General Hospital for Children, Boston, MA, United States of America
⨯
Anne-Maria Fiorino,

Affiliation Division of Global Health, Massachusetts General Hospital for Children, Boston, MA, United States of America
⨯
Christine Botelho,

Affiliation Division of Global Health, Massachusetts General Hospital for Children, Boston, MA, United States of America
⨯
Miriam Haverkamp,

Affiliation Division of Global Health, Massachusetts General Hospital for Children, Boston, MA, United States of America
⨯
Irina Andreyeva,

Affiliation Division of Global Health, Massachusetts General Hospital for Children, Boston, MA, United States of America
⨯
Debra Poutsiaka,

Affiliation Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, United States of America
⨯
Claire Fraser,

Affiliation Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, United States of America
⨯
Gloria Solano-Aguilar,

Affiliation United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics, and Immunology Laboratory, Beltsville, MD, United States of America
⨯
David R. Snydman

Affiliation Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, MA, United States of America
⨯

No Evidence of Harms of Probiotic Lactobacillus rhamnosus GG ATCC 53103 in Healthy Elderly—A Phase I Open Label Study to Assess Safety, Tolerability and Cytokine Responses

Patricia L. Hibberd,
Lauren Kleimola,
Anne-Maria Fiorino,
Christine Botelho,
Miriam Haverkamp,
Irina Andreyeva,
Debra Poutsiaka,
Claire Fraser,
Gloria Solano-Aguilar,
David R. Snydman

Published: December 1, 2014
https://doi.org/10.1371/journal.pone.0113456

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