Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

• Christophe Merceron ,

  Contributed equally to this work with: Christophe Merceron, Laura Mangiavini

  Affiliations Department of Orthopaedic Surgery, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America, Inserm, UMRS 791-LIOAD, Centre for Osteoarticular and Dental Tissue Engineering, Group STEP ‘Skeletal Tissue Engineering and Physiopathology’, Nantes, France, LUNAM, Nantes University, Faculty of Dental Surgery, Nantes, France

  ⨯
• Laura Mangiavini ,

  Contributed equally to this work with: Christophe Merceron, Laura Mangiavini

  Affiliations Department of Orthopaedic Surgery, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Orthopaedic and Traumatology, Milano-Bicocca University, Monza (MB), Italy

  ⨯
• Alexander Robling,

  Affiliation School of Medicine, Department of Anatomy and Cell Biology, Indiana University, Indianapolis, Indiana, United States of America

  ⨯
• Tremika LeShan Wilson,

  Affiliation Department of Orthopaedic Surgery, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Amato J. Giaccia,

  Affiliation School of Medicine, Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California, United States of America

  ⨯
• Irving M. Shapiro,

  Affiliation Department of Orthopaedic Surgery and Graduate Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

  ⨯
• Ernestina Schipani ,

  * E-mail: Makarand.Risbud@jefferson.edu (MVR); eschipan@med.umich.edu (ES)

  Affiliations Department of Orthopaedic Surgery, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Medicine, Division of Endocrinology, Medical School, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Makarand V. Risbud

  * E-mail: Makarand.Risbud@jefferson.edu (MVR); eschipan@med.umich.edu (ES)

  Affiliation Department of Orthopaedic Surgery and Graduate Program in Cell and Developmental Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

  ⨯