Elevated Levels of FMR1 mRNA in Granulosa Cells Are Associated with Low Ovarian Reserve in FMR1 Premutation Carriers

Shai E. Elizur; Oshrit Lebovitz; Sanaz Derech-Haim; Olga Dratviman-Storobinsky; Baruch Feldman; Jehoshua Dor; Raoul Orvieto; Yoram Cohen

doi:10.1371/journal.pone.0105121

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Peer-reviewed

Research Article

Elevated Levels of FMR1 mRNA in Granulosa Cells Are Associated with Low Ovarian Reserve in FMR1 Premutation Carriers

Shai E. Elizur ,

¶SEE and OL should be regarded as joint first authors on this work.

Affiliation Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, (Tel Hashomer), Ramat Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Oshrit Lebovitz ,

¶SEE and OL should be regarded as joint first authors on this work.

Affiliation Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, (Tel Hashomer), Ramat Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Sanaz Derech-Haim,

Affiliation Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, (Tel Hashomer), Ramat Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Olga Dratviman-Storobinsky,

Affiliation Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, (Tel Hashomer), Ramat Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Baruch Feldman,

Affiliation Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, (Tel Hashomer), Ramat Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Jehoshua Dor,

Affiliation Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, (Tel Hashomer), Ramat Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Raoul Orvieto,

Affiliation Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, (Tel Hashomer), Ramat Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯
Yoram Cohen

* E-mail: ycohen1@gmail.com

Affiliation Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, (Tel Hashomer), Ramat Gan, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
⨯

Elevated Levels of FMR1 mRNA in Granulosa Cells Are Associated with Low Ovarian Reserve in FMR1 Premutation Carriers

Shai E. Elizur,
Oshrit Lebovitz,
Sanaz Derech-Haim,
Olga Dratviman-Storobinsky,
Baruch Feldman,
Jehoshua Dor,
Raoul Orvieto,
Yoram Cohen

Published: August 25, 2014
https://doi.org/10.1371/journal.pone.0105121

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DNA methylation
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Granulosa cells
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Oocytes
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Mutation
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